姓名：杜鑫哲 性别：女 政治面貌：中共党员 学历：研究生 学位：博士 职称：讲师
博、硕导师：硕士研究生导师 本岗位工作年数：6
研究方向：
精神疾病的基础与临床转化
荣誉称号：
学术任职：
山西省预防医学会残疾预防与控制专业委员会委员
近五年承担科研课题情况：
1.国家自然科学基金青年项目，项目名称：硫化氢硫巯基化修饰Birc6调节“凋亡-突触修剪”改善精神分裂症认知损伤的研究，项目编号：82501806，2026.1-2028.12,30万元，在研，主持。
2.山西省自然科学基金青年项目，项目名称：外泌体circRNA/miR-26a-5p/PDE4B轴在早发型精神分裂症中的作用机制研究，项目名称：202203021212038，2023-01至2025-12, 5万元，结题，主持。
代表性论著及近五年的代表性论文（限10项以内）：
1.Xinzhe Du#, Wei Hu#, Meiqi Liu, Jinzhi Lv, Yao Gao, Xiao Wang, Wentao Zhao, Junxia Li, Xinrong Li, Xiaohua Cao, Zhifen Liu, Yong Xu*, Sha Liu*. Hydrogen sulfide alleviates schizophrenia-like behavior through regulating apoptosis by S-sulfhydrylation modification. CNS Neuroscience & Therapeutics, 2025; 31:e70278. (IF:5, 1区）
2.Xinzhe Du, Wei Hu, Xinrong Li, Yao Gao, Junxia Li , Xiaodong Hu, Xiao Wang, Wentao Zhao, Long Cheng, Xiaohua Cao, Hongbao Cao, Zhiyong Ren, Yu Zhang, Yong Xu, Sha Liu. CircRNA-miRNA-mRNA networks in plasma extracellular vesicles as biomarkers for first-onset schizophrenia. BMC psychiatry,2025, 25:688. (IF:3.6 , 2区）
3.Meiqi Liu#,Xinzhe Du#, Kaiyao Xue, Yao Gao, Xiaohua Cao, Junxia Li, Sha Liu*. Targeted metabolomics study on peripheral blood neurotransmitters in early-onset schizophrenia. Journal of Translational Medicine 2025,23, 1238. (IF:7.5, 2区）
4.Xinzhe Du#, Yukun Wang#, Qian Zhang#, Yao Gao, Xiao Wang, Wentao Zhao, Xiaodong Hu, Yu Zhang, Yong Xu, Bo Chen, Jihui Zhang, Sha Liu, Xinrong Li. Influence of Polymorphisms in Gene SATB2 on Antipsychotics Response in Chinese Han Population. Neuropsychiatric Disease and Treatment. 2025 25; 21:1495-1505 (IF 2.9 3区).
5.Zexuan Li#,Xinzhe Du#, Xijin Wang#, JianZhen Hu, MeiQi Liu, Yao Gao, Zhifen Liu, Xiaohua Cao, Xinrong Li, Yong Xu, Sha Liu*. The neurodevelopmental regulatory role and clinical value of hsa-circ-CORO1C-hsa-miR-708-3p-JARID2 + LNPEP axis in early-onset schizophrenia. NPJ Schizophrenia. 2024 Dec 19;10(1):119. (IF 5.7 2区)
6.Jinzhi Lv#,Xinzhe Du#, Qian Wu, Yao Gao,Wentao Zhao,Xiao Wang, Yue Li, Junxia Li, Xiaohua Cao, Xinrong Li, Yong Xu, Yu Zhang, Zhiyong Ren, Sha Liu*. Plasma levels of hydrogen sulfide and homocysteine correlate with the efficacy of antidepressant agents and serve as potential diagnostic and therapeutic markers. Nitric Oxide. 2024 Apr 1;145:33-40. (IF 3.9 2区）
7.Xinzhe Du, Jinzhi Lv, Jianping Feng, Xinrong Li, Yao Gao, Xiao Wang, Wentao Zhao, Zhiyong Ren, Ruifang Zhang, Xiaohua Cao, Sha Liu*, Yong Xu*. Plasma exosomes lncRNA-miRNA-mRNA network construction and its diagnostic efficacy identification in first-episode schizophrenia. BMC psychiatry, 2023, 23:611. (IF: 4.14, 2区）
8.Guangxian Wu†,Xinzhe Du†, Zexuan Li, Yanhong Du , Jinzhi Lv, Xinrong Li , Yong Xu，Sha Liu*. The emerging role of long non-coding RNAs in schizophrenia. Frontiers in Psychiatry, 2022 Sep 26;13:995956. (IF: 5.435, 3区）
9.Luyao Huo†,Xinzhe Du†, Xinrong Li, Sha Liu*, Yong Xu*. The Emerging Role of Neural Cell-Derived Exosomes in Intercellular Communication in Health and Neurodegenerative Diseases, Frontiers in Neuroscience, 2021, 15: 738442. (IF: 4.677,二区）
10.Xinzhe Du, Zhuping Jin, Zhiqiang Liu, Liping Zhang, Xiaoli Ma, Guangdong Yang, Sha Liu, Yarong Guo, Yanxi Pei*. H2S persulfidated and increased kinase activity of MPK4 to response cold stress in Arabidopsis. Frontiers in Molecular Biosciences, 2021, 8:635470. (IF: 5.246, 2区)
